Need content

Important Pregnancy and Breastfeeding Warning for Spironolactone

Spironolactone Pregnancy Warnings:

Use is considered contraindicated; use during pregnancy requires the benefit be weighed against the risk to the fetus.

US FDA pregnancy category: C

Comments: Adequate methods of contraception should be encouraged.

Animal studies have revealed an increased resorption rate, decreased live fetuses, and progestational and antiandrogenic effects. There are no controlled data in human pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Spironolactone Breastfeeding Warnings:

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Yes (as active metabolite)
According to some authorities, use of this drug appears acceptable during breastfeeding.